Why Bryan Johnson Changed his Mind on his Extreme Longevity Protocols

12 May 2024 (11 months ago)

Intro (0s)

Bryan Johnson changed his life to reverse his age and increase his lifespan.
He is curious about how his ideas and theories on longevity have changed over the last decade.

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Bryan Johnson noticed an increase in nighttime erections after undergoing electromagnetic shock therapy and targeted muscle strengthening.
Nighttime erections are a significant indicator of biological age, sexual function, and psychological health.
A device called the Cube Squared was used to measure the duration and quality of nighttime erections.
Initially, Johnson's nighttime erections lasted for 132 minutes, which was within the normal range for his chronological age of 46.
After undergoing focused shock wave therapy and Botox injections in the penis, Johnson's nighttime erections increased to 179 minutes, surpassing the average duration for 18-year-olds.
Nighttime erections tend to peak between the ages of 20 and 29, with an average duration of around 165 minutes.
There is a significant drop in nighttime erection duration between the ages of 45 and 49.

Bryan Johnson changed his mind on the idea that "if one is good, two must be better".
He found that taking two drops of liquid iodine per day, instead of the recommended one drop, put him outside the reference range for a certain marker.
He learned that "two is not better" and that the most precise amount should be found and followed.
Taking more than the recommended amount of a supplement can have detrimental effects.
The goal is to find the minimum effective dose for everything.

Bryan Johnson's speed of aging was measured using DNA methylation patterns.
Certain therapies increased his speed of aging, including a senolytic profile of daip and curs, and HGH therapy to rejuvenate his thymus.
After discontinuing these therapies, his speed of aging returned to baseline.
There is a trade-off in therapies, not all things are universally good, some have negative consequences.
Bryan Johnson's speed of aging dropped to his lowest ever, 64, which is exceptionally low for a 46-year-old.
Only two therapies may have caused this lowering: a peptide regimen and Festa gene therapy.
It is unclear which therapy was responsible for the improvement.

Bryan Johnson has revised his extreme longevity protocols, prioritizing sleep as the most crucial factor in his overall health and well-being.
He emphasizes the significance of optimal sleep for intellectual performance, particularly when tackling complex problems and contemplating the future of intelligent existence.
Johnson believes that sleep deprivation severely impairs clear thinking and mental clarity.
His ideal sleep routine involves creating a blackout environment, utilizing white noise, and waking up naturally without an alarm.
After experiencing sleep disruption due to his son's frequent nighttime wake-ups, Johnson realized the profound impact of sleep on his health and well-being.
He now focuses on maintaining a resting heart rate of 47 bpm as an objective indicator of good sleep quality.
Johnson stresses the importance of valuing sleep and investing emotional significance in it to maximize its benefits.
He avoids making crucial life decisions during periods of poor sleep, recognizing its detrimental effects on his mental and emotional state.
To enhance sleep quality, Johnson practices a "sleep divorce" from his wife, sleeping in separate rooms to minimize disturbances.
He also recommends maintaining a comfortable bedroom temperature, around 73 degrees Fahrenheit in the winter and 67 degrees Fahrenheit in the summer.

Bryan Johnson believes it is the right time to set our sights on conquering death.
He thinks we can meaningfully change how we think about aging, deterioration, rejuvenation, and life extension.
Johnson doesn't claim to have solved immortality but believes we can change the game of decay and death.
He suggests that this should become the singular game for humanity, individually, collectively, and for AI.
Johnson acknowledges that we may not achieve immortality but wants to prolong life with a good quality of life.
He compares the human body to a Toyota Camry that will eventually break down but can be maintained to extend its lifespan.